John Crenshaw embarks on a weekend getaway with his girlfriend and her students for a nature photography trip in the woods. What begins as a chance for creativity and bonding quickly devolves into a nightmare when they are hunted by a terrifying group of grotesquely mutated humans driven by a relentless thirst for blood. As chaos ensues and the situation spirals out of control, Crenshaw emerges as the group's last hope for survival against the horrifying onslaught.