When night guard Larry Daley inadvertently activates a long-dormant curse, the natural history museum transforms into a battleground of history. Awakened from their slumber, Attila the Hun, a legion of gladiators, a towering Tyrannosaurus rex, and countless other exhibits spring to life, plunging the museum into delightful pandemonium. As Larry navigates this unexpected chaos, he must find a way to restore order before dawn breaks, ensuring that these remarkable figures return to their displays before the world discovers their secret.