After experiencing her eleventh breakup, Frankie uncovers the existence of a "loser in love" gene that dooms her to perpetual heartbreak. Frustrated and determined to alter her romantic destiny, she sets off on a mission to defy her genetic fate. Along the way, Frankie explores the complexities of love and self-discovery, seeking to break the cycle of rejection that has plagued her relationships. With humor and resilience, she confronts her past and challenges the notion that her love life is predetermined.