In the bustling streets of New York City, detective Luigi Mackeroni delves into a bizarre case involving a series of gruesome penile disfigurements at the notorious Hotel Quickie. His investigation takes a turn when a sexual encounter with a gigolo leads to a shocking incident: a voracious condom attacks and bites off his right testicle. This shocking event propels Mackeroni into a relentless mission to track down and eliminate the dangerous contraceptive that has turned lethal, as he races against time to prevent further chaos.