Mame Dennis, a spirited and unconventional woman in the roaring twenties, suddenly finds herself responsible for her young nephew, Patrick, following the death of his affluent father. As Mame introduces Patrick to a vibrant and free-spirited life, tensions arise with the estate's executor, who disapproves of her bohemian ways. Determined to preserve their bond and lifestyle, Mame fiercely resists attempts to send Patrick off to a stuffy prep school, leading to a delightful clash of values and a celebration of familial love and individuality.